TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects.
Oral Dis
; 15(1): 82-7, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-18992018
ABSTRACT
OBJECTIVES:
The aim of this study was to evaluate tumor necrosis factor (TNF)-alpha and interleukin (IL)-4 levels in healthy sites and sites exhibiting signs of moderate and advanced generalized aggressive periodontitis (GAgP) in the same subject.METHODS:
The following sites were selected for crevicular fluid sampling in the same AgP subject (n = 14) Healthy sites (HS) no marginal bleeding or bleeding on probing (BOP) and probing depth (PD)RESULTS:
The total amount of TNF-alpha was lower for control sites, while there were no differences among healthy and diseased sites from GAgP subjects (P < 0.05). The concentration of TNF-alpha was higher in HS, in relation to the other sites (P < 0.05). There were no significant differences among the groups regarding total amounts of IL-4 (P > 0.05), while IL-4 concentration was significantly higher in control sites, when compared with sites from GAgP subjects (P < 0.05).CONCLUSION:
In conclusion, high levels of TNF-alpha and low levels of IL-4 were observed in both healthy and diseased sites within the same generalized AgP individuals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Periodontite Agressiva
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Interleucina-4
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Fator de Necrose Tumoral alfa
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article