Effect of denervation and ischemia reperfusion injury on serum nitric oxide levels in rats.
Saudi Med J
; 29(11): 1561-6, 2008 Nov.
Article
em En
| MEDLINE
| ID: mdl-18998001
ABSTRACT
OBJECTIVE:
To evaluate the effect of renal denervation and serum nitric oxide level with a different time course of renal ischemia-reperfusion injury.METHODS:
Thirty-six male Wistar rats were randomized into 6 groups. All rats underwent right nephrectomy to create a single kidney model. Renal denervated and innerved rats were subjected to renal clamping for 30-60 minutes. The study was performed in the Department of Anatomy, Akdeniz University, Antalya, Turkey, between June and November 2005.RESULTS:
Combined effect of denervation and ischemia may caused significant increase in serum nitric oxide levels and decrease in glomerular filtration rates.CONCLUSION:
Our results indicate that kidney denervation did not cause any changes in renal functions, but with ischemia it worsens the deleterious effect of ischemia-reperfusion injury, and causes a significant increase in serum nitric oxide levels.
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Base de dados:
MEDLINE
Assunto principal:
Traumatismo por Reperfusão
/
Denervação
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article