[Allotransplantation of Leydig cells increases serum testosterone in rats].

OBJECTIVE: To observe the changes of serum testosterone after allotransplantation of Leydig cells in rats. METHODS: Leydig cells were isolated from the testes of SD rats with the Percoll technique and serum testosterone of the receptors was determined once a month for 3 successive times. RESULTS: After allotransplantation of Leydig cells, the serum testosterone level of the receptors increased gradually, significantly higher at 3 months than that of the normal rats younger than 2 months old. CONCLUSION: Allotransplantation of Leydig cells has a promising application value in the treatment of male primary hypogonadism.