Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice.
Res Vet Sci
; 86(3): 414-20, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19007952
ABSTRACT
A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both T(h)1 and T(h)2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas de DNA
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Mycoplasma agalactiae
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Fator Gênico 3 Estimulado por Interferon, Subunidade gama
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Infecções por Mycoplasma
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article