PTEN deficiency is a common defect in juvenile myelomonocytic leukemia.
Leuk Res
; 33(5): 671-7, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19010541
ABSTRACT
The biological hallmark of juvenile myelomonocytic leukemia (JMML) is selective GM-CSF hypersensitivity. We hypothesized that PTEN protein deficiency might lead to insufficient negative growth signals to counter the hyperactive Ras signaling and therefore aid in the acceleration of the malignant transformation of JMML. In screening 34 JMML patients we found (1) decreased PTEN protein in 67% of patients; (2) significantly lower PTEN mRNA levels in patients compared to controls (p<0.01); (3) a hypermethylated PTEN promoter in 77% of patients; and (4) constitutive-hyperactive Akt and MAPK in 55% and 73% of patients, respectively. These findings suggest that PTEN deficiency is very common in JMML and is in part due to hypermethylation of the PTEN gene promoter.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
PTEN Fosfo-Hidrolase
/
Leucemia Mielomonocítica Juvenil
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article