No evidence for shared etiology in two demyelinative disorders, MS and PLOSL.
J Neuroimmunol
; 206(1-2): 86-90, 2009 Jan 03.
Article
em En
| MEDLINE
| ID: mdl-19019460
ABSTRACT
Loss-of-function mutations of DAP12 and TREM2 cause a recessively inherited disease PLOSL, manifesting in brain white matter. The genes of the DAP12-TREM2 signaling receptor are located on 19q13.12 and 6p21.1, to which linkage has been observed also in families affected by another immune-mediated demyelinating disease, MS. We have tested if allelic variation in DAP12 or TREM2 predisposes also to MS by monitoring carrier frequency of the Finnish PLOSL mutation in Finnish MS cases and by studying DAP12 and TREM2 in MS by linkage and association. To conclude, the DAP12-TREM2 complex unlikely has a role in genetic susceptibility of MS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
/
Doenças Desmielinizantes
/
Predisposição Genética para Doença
Tipo de estudo:
Etiology_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article