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Beyond the MEK-pocket: can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?
Tecle, Haile; Shao, Jianxing; Li, Yanhong; Kothe, Michael; Kazmirski, Steven; Penzotti, Julie; Ding, Yuan-Hua; Ohren, Jeffrey; Moshinsky, Deb; Coli, Rocco; Jhawar, Nidhi; Bora, Emilia; Jacques-O'Hagan, Suzanne; Wu, Joe.
Afiliação
  • Tecle H; Pfizer Global Research and Development, Research Technology Center, Cambridge, MA 02139, USA. haile.tecle@pfizer.com
Bioorg Med Chem Lett ; 19(1): 226-9, 2009 Jan 01.
Article em En | MEDLINE | ID: mdl-19019675
ABSTRACT
An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket or pockets closely related to it may exist in kinases other than MEK.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2009 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinases de Proteína Quinase Ativadas por Mitógeno / Inibidores de Proteínas Quinases Idioma: En Ano de publicação: 2009 Tipo de documento: Article