Increased risks of congenital, neurologic, and endocrine disorders associated with autism in preschool children: cognitive ability differences.
J Pediatr
; 154(3): 345-50, 350.e1, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19028388
ABSTRACT
OBJECTIVE:
To investigate the increased risk of congenital, neurologic, and endocrine disorders in autistic preschool children and to probe possible cognitive impairment-associated variation in such risks. STUDYDESIGN:
Using a population-based longitudinal study, a total of 3440 autistic children born in 1997-1999 and 33,391 age- and residential urbanicity-matched control subjects were identified from the National Health Insurance Research Database in Taiwan. Conditional logistic analyses were performed to estimate the strength of association stratified by the presence of cognitive impairment.RESULTS:
Autistic children were found to have greatly elevated risks of congenital anomalies (eg, tuberous sclerosis adjusted odds ratio [aOR] = 34 approximately 61) and neurologic disorders (eg, epilepsy aOR = 5 approximately 13) compared with their matched nonautistic peers. The increased risk of medical diseases for mentally retarded autism were approximately 1.6 to 9 times greater than those for isolated autism.CONCLUSIONS:
The observed cognitive impairment-related variation in the increased risk of congenital, neurological, and endocrine disorders with autism may provide some clinical and etiologic implications that warrant investigation in the future.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transtorno Autístico
/
Anormalidades Congênitas
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Transtornos Cognitivos
/
Doenças do Sistema Endócrino
/
Doenças do Sistema Nervoso
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article