Failure of two distinct anti-apoptotic approaches to reduce mortality in experimental cerebral malaria.
Am J Trop Med Hyg
; 79(6): 823-5, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-19052286
ABSTRACT
Cerebral malaria is responsible for a high proportion of mortality in human Plasmodium falciparum infection. Previous studies have reported the presence of apoptosis in endothelial cells, astrocytes, neurons, and glial cells in experimental murine cerebral malaria caused by infection with Plasmodium berghei ANKA. Using this model, we tested two strategies, which have been shown to improve survival in murine models of sepsis 1) treatment with z-VAD, a pancaspase inhibitor; and 2) overexpression of Bcl-2 using transgenic mice expressing human Bcl-2 (which prevents the release of apoptotic mediators from the mitochondria) from a myeloid cell promoter. Neither of these anti-apoptotic strategies, previously shown to provide therapeutic benefit in sepsis, improved survival in experimental cerebral malaria.
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Base de dados:
MEDLINE
Assunto principal:
Oligopeptídeos
/
Malária Cerebral
/
Apoptose
/
Proteínas Proto-Oncogênicas c-bcl-2
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article