Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells.
Cancer Lett
; 276(2): 152-9, 2009 Apr 18.
Article
em En
| MEDLINE
| ID: mdl-19059704
ABSTRACT
Like Dickkopf-1 (DKK1), DKK4 is a target of beta-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal beta-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Peptídeos e Proteínas de Sinalização Intercelular
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article