Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.

Czaplewski, Lloyd G; Collins, Ian; Boyd, E Andrew; Brown, David; East, Stephen P; Gardiner, Mihaly; Fletcher, Rowena; Haydon, David J; Henstock, Vincent; Ingram, Peter; Jones, Clare; Noula, Caterina; Kennison, Leanne; Rockley, Chris; Rose, Valerie; Thomaides-Brears, Helena B; Ure, Rebecca; Whittaker, Mark; Stokes, Neil R

Czaplewski, Lloyd G; Collins, Ian; Boyd, E Andrew; Brown, David; East, Stephen P; Gardiner, Mihaly; Fletcher, Rowena; Haydon, David J; Henstock, Vincent; Ingram, Peter; Jones, Clare; Noula, Caterina; Kennison, Leanne; Rockley, Chris; Rose, Valerie; Thomaides-Brears, Helena B; Ure, Rebecca; Whittaker, Mark; Stokes, Neil R.

Afiliação

Czaplewski LG; Prolysis Ltd, Begbroke Science Park, Sandy Lane, Yarnton, Oxfordshire OX5 1PF, UK.

Bioorg Med Chem Lett ; 19(2): 524-7, 2009 Jan 15.

Article em En | MEDLINE | ID: mdl-19064318

ABSTRACT

ABSTRACT

3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/antagonistas & inibidores; Benzamidas/farmacologia; Proteínas do Citoesqueleto/antagonistas & inibidores; Staphylococcus/efeitos dos fármacos; Antibacterianos/química; Benzamidas/química; Testes de Sensibilidade Microbiana; Relação Estrutura-Atividade

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Staphylococcus / Proteínas de Bactérias / Benzamidas / Proteínas do Citoesqueleto / Antibacterianos Idioma: En Ano de publicação: 2009 Tipo de documento: Article

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