Does preterm birth influence the response to growth hormone treatment in short, small for gestational age children?
Clin Endocrinol (Oxf)
; 70(4): 582-7, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19067725
ABSTRACT
OBJECTIVE:
To investigate whether prematurity has an independent influence on the response to GH treatment in short, small for gestational age (SGA) children.DESIGN:
A longitudinal 3-year GH study. PATIENTS A total of 392 prepubertal non-GH-deficient, short SGA children, comprising 138 preterm (< 36 weeks) and 254 term (>or= 36 weeks) children. MEASUREMENTS Height, weight, head circumference, skinfolds and serum IGF-I and IGFBP-3 levels were measured before start of GH treatment and after 6 months, 1, 2 and 3 years of treatment.RESULTS:
Preterm short SGA children were significantly lighter and shorter at birth after correction for gestational age than term short SGA children (P < 0.001). At start of GH treatment, preterm children were significantly shorter than term children when height was corrected for target height (TH). Preterm children were also significantly leaner as shown by a lower body mass index (BMI) standard deviation score (SDS) and a lower sum of four skinfolds SDS. Prematurity had no influence on childhood IGF-I and IGFBP-3 levels. The response to GH treatment was similar for preterm and term SGA children.CONCLUSIONS:
Within a population of short SGA children, prematurity is associated with a smaller size for gestational age and a shorter height corrected for TH and leaner phenotype in childhood. The response to GH treatment is similar for preterm and term short SGA children.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estatura
/
Hormônio do Crescimento
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Idade Gestacional
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Nascimento Prematuro
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article