[The metabolic syndrome and type-2 diabetes mellitus as conditions predisposing for malignant tumors]. / A metabolikus szindróma és a 2-es típusú diabetes mellitus mint rosszindulatú daganatra hajlamosító állapotok.
Orv Hetil
; 149(51): 2403-11, 2008 Dec 21.
Article
em Hu
| MEDLINE
| ID: mdl-19073451
ABSTRACT
Recently more and more evidences have emerged about the oncogenic effect of type 2 diabetes and metabolic syndrome. Among these evidences epidemiological data are in first line. There is a causal relationship according to gender, ethnicity and geographic situation between different tumors and type 2 diabetes/metabolic syndrome as well. Supposed pathomechanisms are obesity, cytokines, secreted excessively in adipose tissue, permanent and postprandial hyperglycemia, hyperinsulinism and insulin resistance, other growth factors, like proinsulin, insulin like growth factor-1, reactive oxygen species, angiogenesis, inflammation, and the multiple effects of inflammatory cytokines. It proved to be evident that both peroxisome-proliferator-activated receptors and the regulatory ubiquitin proteasome system have significant role in insulin sensitivity and in co-ordinating cell proliferation and angiogenesis. These mechanisms in metabolic syndrome are risk factors towards atherosclerosis and cancer diseases as well. This newly emerged knowledge may open new pathways in treating and preventing the above-mentioned pathologic processes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome Metabólica
/
Diabetes Mellitus Tipo 2
/
Neoplasias
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
Hu
Ano de publicação:
2008
Tipo de documento:
Article