Identity of a biliary metabolite formed from monocrotaline in isolated, perfused rat liver.
Toxicon
; 29(4-5): 409-15, 1991.
Article
em En
| MEDLINE
| ID: mdl-1907409
ABSTRACT
A pneumotoxic pyrrolic metabolite, previously isolated from the bile when rat liver was perfused with the pyrrolizidine alkaloid, monocrotaline, has been identified as 7-glutathionyl-dehydroretronecine. The metabolite showed a TLC spot and HPLC peak corresponding with the latter compound, and a procedure for replacing the thioether group with an ethoxy group converted the metabolite to dehydroretronecine 7-ethyl ether, confirming that the glutathionyl moiety was attached to the 7-position of dehydroretronecine. The same metabolite was detected in bile from rat liver perfused with retrorsine, which is a diester alkaloid similar to monocrotaline, whereas it was not formed from heliotrine, an alkaloid lacking the 7-ester function.
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Base de dados:
MEDLINE
Assunto principal:
Alcaloides de Pirrolizidina
/
Bile
/
Glutationa
/
Fígado
Limite:
Animals
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article