Down-regulation of allergic responses in conditions of experimental diabetes: a role for glucocorticoids?
Neuroimmunomodulation
; 16(1): 13-8, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19077441
ABSTRACT
The prevalence of atopic diseases and diabetes is increasing worldwide, though the co-occurrence of both diseases in the same individual is less frequent than predicted. Previously published studies suggest that the Th1/Th2 concept could explain the inverse relationship between allergic diseases and type 1 diabetes. However, down-regulation of the IgE-mast cell system can also markedly contribute to the lack of responsiveness to local and systemic allergen challenges in diabetic conditions. Moreover, dysregulation of the hypothalamic-pituitary-adrenocortical axis and elevated endogenous glucocorticoid levels play a pertinent role in some of the pathological-related processes associated with poorly controlled or uncontrolled diabetes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Complicações do Diabetes
/
Glucocorticoides
/
Hipersensibilidade
/
Tolerância Imunológica
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article