Oral mucosal cell response to Candida albicans in transgenic mice expressing HIV-1.
Methods Mol Biol
; 470: 359-68, 2009.
Article
em En
| MEDLINE
| ID: mdl-19089395
ABSTRACT
Controlled studies on the immunopathogenesis of mucosal candidiasis in HIV infection have been hampered by the lack of a relevant animal model. We have previously reported that oral Candida infection in CD4C/HIV transgenic mice expressing gene products of HIV-1 in immune cells and developing an AIDS-like disease closely mimics oropharyngeal candidiasis in human HIV infection. The role of defective dendritic cells and CD4+ T cells in impaired induction of protective immunity and in the phenotype of chronic oral carriage of C. albicans can now be investigated under controlled conditions in these transgenic mice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candida albicans
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Candidíase Bucal
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HIV-1
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Infecções Oportunistas Relacionadas com a AIDS
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Mucosa Bucal
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article