RNA under attack: cellular handling of RNA damage.
Crit Rev Biochem Mol Biol
; 44(1): 34-49, 2009.
Article
em En
| MEDLINE
| ID: mdl-19089684
ABSTRACT
Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA
/
Estresse Oxidativo
/
Alquilação
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article