(2,2-Diphenyl-[1,3]oxathiolan-5-ylmethyl)-(3-phenyl-propyl)-amine: a potent and selective 5-HT(1A) receptor agonist.
ChemMedChem
; 4(2): 196-203, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19101959
ABSTRACT
Starting from compound 1, a previously reported alpha(1D)-adrenoceptors antagonist, a new series of ligands acting at 5-HT(1A) serotonin receptor were identified through simple structure modifications. Among them (2,2-diphenyl-[1,3]oxathiolan-5-yl-methyl)-(3-phenyl-propyl)amine (19) exhibits outstanding activity (pK(i)=8.72, pD(2)=7.67, E(max)=85) and selectivity (5-HT(1A)/alpha(1D)>150), and represents an as yet unidentified 5-HT(1A) agonist scaffold.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Agonistas do Receptor de Serotonina
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Agonistas do Receptor 5-HT1 de Serotonina
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Compostos Heterocíclicos com 1 Anel
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article