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How the Dorsal gradient works: insights from postgenome technologies.
Hong, Joung-Woo; Hendrix, David A; Papatsenko, Dmitri; Levine, Michael S.
Afiliação
  • Hong JW; Division of Genetics, Genomics, and Development, Department of Molecular and Cell Biology, Center for Integrative Genomics, University of California, Berkeley, CA 94720, USA.
Proc Natl Acad Sci U S A ; 105(51): 20072-6, 2008 Dec 23.
Article em En | MEDLINE | ID: mdl-19104040
Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of approximately 35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica no Desenvolvimento Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2008 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Regulação da Expressão Gênica no Desenvolvimento Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2008 Tipo de documento: Article