Cytotoxic activity of alkaloids isolated from Stephania rotunda [corrected].
Phytother Res
; 23(4): 587-90, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19107844
ABSTRACT
Three major alkaloids cepharanthine (1), tetrahydropalmatine (2) and xylopinine (3) isolated from Stephania rotunda tuber were investigated for their cytotoxic activity in a panel of human cancer cells (HT29, LS174T, SW620 and HepG2) using MTT assay. In the present study, cepharanthine (1) exerted potent cytotoxicity against colon and hepatoma cancer cell lines with IC(50) values between 2.4 and 5.3 microM while tetrahydropalmatine (2) and xylopinine (3) displayed weak cytotoxicity. In addition, the mutagenic activity of cepharanthine (1) was investigated using a modified liquid incubation technique of the Salmonella/microsomal assay. This alkaloid (1) was found to be non-mutagenic for doses up to 8.2 microM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Stephania
/
Benzilisoquinolinas
/
Alcaloides
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article