[Growth inhibition of prostate cancer cells by epigallocatechin-3-gallate in the presence of Zn2+ in vitro].
Fen Zi Xi Bao Sheng Wu Xue Bao
; 41(6): 443-9, 2008 Dec.
Article
em Zh
| MEDLINE
| ID: mdl-19137815
ABSTRACT
In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Zinco
/
Catequina
Limite:
Humans
/
Male
Idioma:
Zh
Ano de publicação:
2008
Tipo de documento:
Article