[The effect of apolipoprotein e polymorphism on plasma cholesteryl ester transfer protein activity in type 2 diabetic patients].
Mol Biol (Mosk)
; 42(6): 931-6, 2008.
Article
em Ru
| MEDLINE
| ID: mdl-19140312
ABSTRACT
We studied the relationship between apo E polymorphism and cholesteryl ester transfer protein (CETP) activity in 127 type 2 diabetic patients who did not take lipid lowering drugs. Furthermore, we studied the relationship between apo E and CETP in modulating plasma triglyceride and HDL cholesterol. Apo E genotypes were determined by PCR-RFLP and CETP activity was measured using an exogenous way. Our results showed that the CETP activity increased significantly in E2 carrier group compared to E4 carriers and E3E3 homozygous (84.7 +/- 43.9 vs 62.5 +/- 35.9 vs 52.6 +/- 23.6 nmol CE/ml 2h respectively; p = 0.015). However, there was no association between apoE polymorphism and lipid parameter variations. Even after adjustment for CETP activity the results remained unchanged showing that CETP did not step in the relationship between apo E and lipid parameter variations. In conclusion there is an association between apo E polymorphism and CETP activity and this association did not affect the relationship between apo E polymorphism and triglyceride and HDL cholesterol concentrations.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo de Fragmento de Restrição
/
Diabetes Mellitus Tipo 2
/
Proteínas de Transferência de Ésteres de Colesterol
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Africa
Idioma:
Ru
Ano de publicação:
2008
Tipo de documento:
Article