Artifacts in Fourier transform mass spectrometry.
Rapid Commun Mass Spectrom
; 23(4): 523-9, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19142849
ABSTRACT
Recent work on a new, higher sensitivity preamplifier design for Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS) revealed a number of artifact peaks (spectral features) which do not contain useful chemical information. In order to determine the cause of these artifacts and eliminate them, these severely distorted spectra were compared with similarly distorted signal models. The source of several common signal processing artifacts was thereby determined and correlated to radio-frequency interference (RFI) noise and saturation of the amplifier and/or the digitizer. Under such conditions, the fast Fourier transform (FFT) generates spectral artifact peaks corresponding to harmonics and mixing frequencies of the real signal peaks and RFI frequencies. While this study was done using FTICRMS data, it is important to stress that these artifacts are inherent to the digitization and FFT process and thus are relevant to any FT-based MS instrument, including the orbitrap and FT ion trap.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
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Artefatos
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Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
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Espectrometria de Massas por Ionização por Electrospray
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Eletrônica
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Falha de Equipamento
Tipo de estudo:
Diagnostic_studies
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Evaluation_studies
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Prognostic_studies
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article