Synthesis and antimicrobial evaluation of some new substituted purine derivatives.
Bioorg Med Chem
; 17(4): 1693-700, 2009 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-19150600
ABSTRACT
A series of 8,9-disubstituted adenines (4, 5, 8), 6-substituted aminopurines (10-13) and 9-(p-fluorobenzyl/cyclopentyl)-6-substituted aminopurines (16, 17, 19-30) have been prepared and the antimicrobial activities of these compounds against Staphylococcus aureus, methicillin-resistant S. aureus (MRSA, standard and clinical isolate), Bacillus subtilis, Escherichia coli and Candida albicans were evaluated. 6-[(N-phenylaminoethyl)amino]-9H-purine (12) which has no substitution at N-9 position and 9-cyclopentyl-6-[(4-fluorobenzyl)amino]-9H-purine (24) exhibited excellent activity against C. albicans with MIC 3.12 microg/mL. These compounds displayed better antifungal activity than that of standard oxiconazole. Furthermore, compound 22 carrying 4-chlorobenzylamino group at the 6-position of the purine moiety exhibited comparable antibacterial activity with that of the standard ciprofloxacin against both of the drug-resistant bacteria (MRSA, standard and clinical isolate).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Purinas
/
Anti-Infecciosos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article