Na,K-ATPase signal transduction triggers CREB activation and dendritic growth.
Proc Natl Acad Sci U S A
; 106(7): 2212-7, 2009 Feb 17.
Article
em En
| MEDLINE
| ID: mdl-19164762
ABSTRACT
Dendritic growth is pivotal in the neurogenesis of cortical neurons. The sodium pump, or Na,K-ATPase, is an evolutionarily conserved protein that, in addition to its central role in establishing the electrochemical gradient, has recently been reported to function as a receptor and signaling mediator. Although a large body of evidence points toward a dual function for the Na,K-ATPase, few biological implications of this signaling pathway have been described. Here we report that Na,K-ATPase signal transduction triggers dendritic growth as well as a transcriptional program dependent on cAMP response element binding protein (CREB) and cAMP response element (CRE)-mediated gene expression, primarily regulated via Ca(2+)/calmodulin-dependent protein (CaM) kinases. The signaling cascade mediating dendritic arbor growth also involves intracellular Ca(2+) oscillations and sustained phosphorylation of mitogen-activated protein (MAP) kinases. Thus, our results suggest a novel role for the Na,K-ATPase as a modulator of dendritic growth in developing neurons.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Proteína de Ligação ao Elemento de Resposta ao AMP Cíclico
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ATPase Trocadora de Sódio-Potássio
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Dendritos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article