Selective determination of ertapenem in the presence of its degradation product.
Spectrochim Acta A Mol Biomol Spectrosc
; 72(5): 915-21, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19167266
ABSTRACT
Stability-indicative determination of ertapenem (ERTM) in the presence of its beta-lactam open-ring degradation product, which is also the metabolite, is investigated. The degradation product has been isolated, via acid-degradation, characterized and elucidated. Selective quantification of ERTM, singly in bulk form, pharmaceutical formulations and/or in the presence of its major degradant is demonstrated. The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are first derivative ((1)D), first derivative of ratio spectra ((1)DD) and bivariate analysis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espectrometria de Fluorescência
/
Beta-Lactamas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article