Effects of estrogen therapy on microalbuminuria in healthy post-menopausal women.
Gynecol Endocrinol
; 24(12): 681-5, 2008 Dec.
Article
em En
| MEDLINE
| ID: mdl-19172536
ABSTRACT
OBJECTIVE:
To evaluate the impact of estrogen therapy on microalbuminuria levels in healthy post-menopausal women.METHODS:
Sixty post-menopausal women were evaluated in a prospective, randomised, double-blind, placebo-controlled study. The patients were randomly allocated to one of two groups to take one pill orally per day containing either 1 mg of 17beta-estradiol (E(2) group) or placebo (placebo group). Prior to initiating treatment and at the end of the sixth treatment month, microalbumin was measured in a 12-h urine sample, and lipid profile (total cholesterol, HDL, LDL and triglycerides) and fasting glucose were evaluated. Comparative intra- and inter-group analyses between the initial and final laboratory parameters were performed using the t-test for paired samples and for independent samples, respectively.RESULTS:
Microalbuminuria levels remained within normal limits throughout the study and no statistically significant differences were found in the intra- or inter-group analyses. With respect to lipid profile, alterations characteristically encountered during use of estrogen replacement therapy were found. No statistically significant variation in glucose levels occurred during the study period.CONCLUSION:
Estrogen replacement therapy had no significant effect on microalbuminuria levels in healthy post-menopausal patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terapia de Reposição de Estrogênios
/
Pós-Menopausa
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Albuminúria
/
Estradiol
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
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Humans
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Middle aged
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article