Reduced levels of GH during GnRH analogue treatment in pubertal short girls born small for gestational age (SGA).
Clin Endocrinol (Oxf)
; 70(6): 914-9, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19178519
ABSTRACT
CONTEXT Several studies showed a decrease in height velocity during GnRH analogue (GnRHa) treatment. No information is available on GH levels during GnRHa treatment in short SGA girls. OBJECTIVE:
To study overnight GH profiles and IGF-I and IGFBP-3 levels in girls with Tanner stage 2 and stage 3, before and after 3 months of GnRHa treatment, and to compare levels with those found in prepubertal short SGA girls. PATIENTS Twenty-four pubertal and 16 prepubertal short SGA girls. INTERVENTION After baseline overnight GH profiles, pubertal girls received leuprorelide acetate depots of 3.75 mg subcutaneously every 4 weeks. OUTCOMEMEASURES:
GH, IGF-I and IGFBP-3 levels.RESULTS:
At baseline, GH levels were comparable to levels found in prepubertal short SGA girls and IGF-I and IGFBP-3 SDS were significantly below the population mean. After 3 months of GnRHa treatment, AUC(0) (P = 0.02), mean (P = 0.02) and maximum GH levels (P = 0.008) had significantly decreased. Mean GH levels were significantly lower than in prepubertal short SGA girls (P = 0.03). Eight girls with more than 40% decrease in mean GH levels also had a significantly greater decrease in IGF-I and IGFBP-3 levels. Mean and maximum GH levels at baseline correlated significantly with those after 3 months of GnRHa treatment.CONCLUSION:
Short SGA girls lack the normal increase in GH levels seen in puberty and have reduced IGF-I and IGFBP-3 levels, which might explain their reduced pubertal growth spurt. GnRHa treatment led to a significant reduction in GH levels. Therefore, combining GnRHa treatment with GH treatment might improve adult height of short SGA girls.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
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Hormônio Liberador de Gonadotropina
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Puberdade
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Hormônio do Crescimento Humano
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Transtornos do Crescimento
Limite:
Adolescent
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Child
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Female
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Humans
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Newborn
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article