Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga.
Planta Med
; 75(6): 647-53, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19214945
ABSTRACT
Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 < or = MIC(80) < or = 4 microg/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X-ray diffraction analysis.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Holothuria
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Fungos
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Glicosídeos
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Antifúngicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article