Intracerebroventricular infusion of cytosine-arabinoside causes prepulse inhibition disruption.
Neuroreport
; 20(4): 371-7, 2009 Mar 04.
Article
em En
| MEDLINE
| ID: mdl-19218868
ABSTRACT
Adult neurogenesis in hippocampus is associated with behaviors such as learning. Hippocampus is involved in the regulation of prepulse inhibition (PPI), but the relationship between neurogenesis and PPI is unexplored. We conducted four experiments to determine the role of neural progenitor cell proliferation in PPI. Intracerebroventricular infusion of cytostatic cytosine arabinoside caused PPI disruption but repeated exposure to PPI sessions prevented the PPI disruption. Corticosterone treatment, which decreases hippocampal cell proliferation, caused PPI disruption, whereas antidepressant and exercise, which increased cell proliferation, did not affect PPI. These results suggest that cell proliferation is involved in the first encounter with PPI test while its importance may decrease upon repeated exposures to the tests.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Reflexo de Sobressalto
/
Citarabina
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Neurogênese
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Inibição Neural
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article