Focal adhesion kinase signaling in cardiac hypertrophy and failure.
Braz J Med Biol Res
; 42(1): 44-52, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19219296
ABSTRACT
Focal adhesion kinase (FAK) is a broadly expressed tyrosine kinase implicated in cellular functions such as migration, growth and survival. Emerging data support a role for FAK in cardiac development, reactive hypertrophy and failure. Data reviewed here indicate that FAK plays a critical role at the cellular level in the responses of cardiomyocytes and cardiac fibroblasts to biomechanical stress and to hypertrophic agonists such as angiotensin II and endothelin. The signaling mechanisms regulated by FAK are discussed to provide insight into its role in the pathophysiology of cardiac hypertrophy and failure.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cardiomegalia
/
Miócitos Cardíacos
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Proteína-Tirosina Quinases de Adesão Focal
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Fibroblastos
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Insuficiência Cardíaca
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article