Immune homeostasis in the respiratory tract and its impact on heterologous infection.
Semin Immunol
; 21(3): 147-55, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19223202
ABSTRACT
Innate immunity at mucosal surfaces requires additional restraint to prevent inflammation to innocuous antigens or commensal microorganisms. The threshold above which airway macrophages become activated is raised by site-specific factors including the receptors for transforming growth factor beta, interleukin 10 and CD200; the ligands for which are produced by, or expressed on, respiratory epithelium. We discuss such site-specific regulation and how this is continually altered by prior infections. Resetting of innate reactivity represents a strategy for limiting excessive inflammation, but in some may pre-dispose to secondary bacterial pneumonia.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
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Infecções Bacterianas
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Antígenos CD
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Receptores de Superfície Celular
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Imunidade Inata
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Antígenos de Superfície
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article