5-Aminopyrimidin-2-ylnitriles as cathepsin K inhibitors.
Bioorg Med Chem Lett
; 19(6): 1658-61, 2009 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-19231183
ABSTRACT
A series of pyrimidine nitrile inhibitors of Cathepsin K with reduced glutathione reactivity has been identified and Molecular Core Matching (MoCoM) has been used to quantify the effect of an amino substituent at C5.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Catepsinas
/
Inibidores de Cisteína Proteinase
/
Nitrilas
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article