Quality control for clinical islet transplantation: organ procurement and preservation, the islet processing facility, isolation, and potency tests.
J Hepatobiliary Pancreat Surg
; 16(2): 131-6, 2009.
Article
em En
| MEDLINE
| ID: mdl-19242650
ABSTRACT
Pancreatic islet transplantation has become one of the ideal treatments for patients with type 1 diabetes mellitus due to improvements in isolation techniques and immunosuppression regimens. In order to ensure the safety and rights of patients, isolated islets need to meet the criteria for regulation as both a biological product and a drug product. For the constant success of transplantation, therefore, all investigators involved in clinical islet transplantation must strive to ensure the safety, purity, and potency of islets in all the phases of clinical islet isolation and transplantation. In this review, we summarize the quality control for clinical islet isolation and transplantation, and the latest topics of pre-transplant islet assessment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Preservação de Órgãos
/
Controle de Qualidade
/
Obtenção de Tecidos e Órgãos
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Transplante das Ilhotas Pancreáticas
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Diabetes Mellitus Tipo 1
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article