[Mapping of point mutations leading to loss of virus ECH011 affinity for receptor DAF (CD55)].

ABSTRACT

Comparative sequence of the structural part of genomes pf the original daf+ clone and two derived daf- mutant clones (101 and 103) was analyzed to map mutations responsible for the loss of affinity for the receptor glycoprotein DAF (CD55). The obtained nucleotide sequences (EU167520, EU167521, EU167522) were deposited in the GenBank. There were single point mutations causing amino acid changes in VP2 protein S145 --> N in clone 101 and G162 --> E in clone 103.