Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.
Science
; 254(5030): 415-8, 1991 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-1925598
ABSTRACT
Dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1 beta. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.
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Base de dados:
MEDLINE
Assunto principal:
Inativadores de Plasminogênio
/
Interleucina-1
/
Dibenzodioxinas Policloradas
Limite:
Humans
Idioma:
En
Ano de publicação:
1991
Tipo de documento:
Article