CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.
Nat Immunol
; 10(4): 427-36, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19270712
ABSTRACT
The production of cytokines such as interferon-gamma and interleukin 17 by alphabeta and gammadelta T cells influences the outcome of immune responses. Here we show that most gammadelta T lymphocytes expressed the tumor necrosis factor receptor family member CD27 and secreted interferon-gamma, whereas interleukin 17 production was restricted to CD27(-) gammadelta T cells. In contrast to the apparent plasticity of alphabeta T cells, the cytokine profiles of these distinct gammadelta T cell subsets were essentially stable, even during infection. These phenotypes were established during thymic development, when CD27 functions as a regulator of the differentiation of gammadelta T cells at least in part by inducing expression of the lymphotoxin-beta receptor and genes associated with trans-conditioning and interferon-gamma production. Thus, the cytokine profiles of peripheral gammadelta T cells are predetermined mainly by a mechanism involving CD27.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Timo
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Subpopulações de Linfócitos T
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Interferon gama
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Receptores de Antígenos de Linfócitos T gama-delta
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Membro 7 da Superfamília de Receptores de Fatores de Necrose Tumoral
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Interleucina-17
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Células Progenitoras Linfoides
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article