[Effects of influenza vaccination on the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients: a cohort study]. / Efectos de la vacunación antigripal sobre el porcentaje de linfocitos T CD4 positivos en pacientes VIH 1/2 positivos: estudio de una cohorte.
Gac Sanit
; 23(4): 315-21, 2009.
Article
em Es
| MEDLINE
| ID: mdl-19286280
ABSTRACT
OBJECTIVE:
To determine the incidence of immunologic change in the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients in the first quarter after influenza vaccination (P-CIR) and to compare the demographic and clinical characteristics associated with this change.METHODS:
We studied 105 patients with HIV/AIDS in a retrospective hospital cohort between 2001-2006. P-CIR was considered as a decrease of >3% in the prevaccination CD4+ percentage. Crude and adjusted OR (sex, age, antiretroviral therapy, clinical stability, prevaccination viremia and prevaccination total CD4) were evaluated by logistic regression (95%CI).RESULTS:
The incidence of P-CIR was 33.3%. P-CIR was persistent in 31.4% for 7 months after vaccination regardless of high prevaccination viremia. No association was found between demographic and clinical variables and P-CIR [crude OR 0.90 (0.17-4.8); adjusted OR 1.09 (0.17-6.8)].CONCLUSIONS:
The results showed that the immunological change after vaccination was not inconsiderable. However, this change was mainly transient.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Influenza
/
Infecções por HIV
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HIV-1
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HIV-2
/
Vacinação
/
Contagem de Linfócito CD4
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
País como assunto:
Europa
Idioma:
Es
Ano de publicação:
2009
Tipo de documento:
Article