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Assessment of fetal cardiac function before and after therapy for twin-to-twin transfusion syndrome.
Van Mieghem, Tim; Klaritsch, Philipp; Doné, Elisa; Gucciardo, Léonardo; Lewi, Paul; Verhaeghe, Johan; Lewi, Liesbeth; Deprest, Jan.
Afiliação
  • Van Mieghem T; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University Hospitals Leuven, Leuven, Belgium.
Am J Obstet Gynecol ; 200(4): 400.e1-7, 2009 Apr.
Article em En | MEDLINE | ID: mdl-19318149
OBJECTIVE: We sought to assess fetal cardiac function in monochorionic twins before and after therapy for twin-to-twin transfusion syndrome (TTTS) and compare it with control subjects. STUDY DESIGN: We conducted prospective longitudinal assessment of fetal cardiac function in cases undergoing curative fetal therapy for TTTS (n = 39) until 4 weeks postoperatively and in uncomplicated monochorionic twins (n = 23). Fetal cardiac function was assessed by the left and right ventricular myocardial performance index, atrioventricular valve flow pattern, ductus venosus a-wave, and umbilical vein pulsations. RESULTS: Nomograms for the myocardial performance index were constructed. Fetal cardiac function was grossly abnormal in recipient twins of TTTS when compared with control subjects (P < .001 for all indices) but normalized by 4 weeks postoperatively. The donor developed abnormal ductus venosus flow and tricuspid regurgitation postoperatively that regressed within 4 weeks. CONCLUSION: The cardiac dysfunction in the recipient twin of TTTS normalizes within 1 month after laser. The donor develops a transient impairment of cardiac function postoperatively.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transfusão Feto-Fetal / Feto / Coração Tipo de estudo: Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transfusão Feto-Fetal / Feto / Coração Tipo de estudo: Observational_studies Limite: Female / Humans / Pregnancy Idioma: En Ano de publicação: 2009 Tipo de documento: Article