Low rates of transmission of SRV-2 and STLV-I to juveniles in a population of Macaca fascicularis facilitate establishment of specific retrovirus-free colonies.
J Med Primatol
; 38(3): 160-70, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-19320800
ABSTRACT
BACKGROUND:
Prevalence of simian retrovirus-2 (SRV-2) and simian T lymphotropic virus type I (STLV-I), was unknown in 337 captive cynomolgus macaques. METHODS ANDRESULTS:
Molecular assays identified 29% of animals as SRV-2 mono-infected, 4% of animals as STLV-I mono-infected and 9% of animals as dual-infected. Of 108 juvenile animals, 83% were SRV-2-negative and no juvenile animal was STLV-I-positive. A subsequent study of juvenile macaques over a period of 2.5 years detected no STLV-I and 10 SRV-2 infections, six of which occurred between testing and day of colony formation. The study also highlighted that an anti-SRV-2 serological response does not presuppose infection. Tissue reservoirs of latent SRV-2 were not identified in suspected SRV-2 infections.CONCLUSIONS:
Low transmissibility of the viruses present in the parental cohort and improved knowledge of the host response to SRV-2 has facilitated the creation of specific-retrovirus-free colonies of cynomolgus macaques.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vírus dos Macacos de Mason-Pfizer
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Vírus Linfotrópico T Tipo 1 de Símios
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Infecções por Retroviridae
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Transmissão Vertical de Doenças Infecciosas
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Macaca fascicularis
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Doenças dos Macacos
Tipo de estudo:
Diagnostic_studies
/
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article