Maturation of inhibitory and excitatory motor cortex pathways in children.
Brain Dev
; 31(7): 562-7, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19329268
ABSTRACT
OBJECTIVE:
To study intracortical inhibition and facilitation with paired-pulse transcranial magnetic stimulation in children, adolescents and adults.METHODS:
Paired-pulse transcranial magnetic stimulation (interstimulus intervals (ISI) 1, 3, 5, 10 and 20 ms) was applied over the primary motor cortex (M1) in 30 healthy subjects (range 6-30 years, median age 15 years and 8 months, SD 7,9) divided in three groups adults (>or=18 years), adolescents (> 10 and < 18 years) and children (CONCLUSION:
We postulate that, as in adults, the maturing M1 possesses horizontal glutamatergic cross-links that represent the neuronal substrate of excitatory intracortical pathways. GABAergic interneurons, the neuronal substrate of inhibitory intracortical pathways, mature between childhood and adulthood. Reduced GABAergic inhibition may facilitate neuronal plasticity and motor learning in children.
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
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Córtex Motor
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Inibição Neural
Limite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article