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GCN5 is a required cofactor for a ubiquitin ligase that targets NF-kappaB/RelA.
Mao, Xicheng; Gluck, Nathan; Li, Duo; Maine, Gabriel N; Li, Haiying; Zaidi, Iram W; Repaka, Aparna; Mayo, Marty W; Burstein, Ezra.
Afiliação
  • Mao X; Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA.
Genes Dev ; 23(7): 849-61, 2009 Apr 01.
Article em En | MEDLINE | ID: mdl-19339690
The transcription factor NF-kappaB is a critical regulator of inflammatory and cell survival signals. Proteasomal degradation of NF-kappaB subunits plays an important role in the termination of NF-kappaB activity, and at least one of the identified ubiquitin ligases is a multimeric complex containing Copper Metabolism Murr1 Domain 1 (COMMD1) and Cul2. We report here that GCN5, a histone acetyltransferase, associates with COMMD1 and other components of the ligase, promotes RelA ubiquitination, and represses kappaB-dependent transcription. In this role, the acetyltransferase activity of GCN5 is not required. Interestingly, GCN5 binds more avidly to RelA after phosphorylation on Ser 468, an event that is dependent on IKK activity. Consistent with this, we find that both GCN5 and the IkappaB Kinase (IKK) complex promote RelA degradation. Collectively, the data indicate that GCN5 participates in the ubiquitination process as an accessory factor for a ubiquitin ligase, where it provides a novel link between phosphorylation and ubiquitination.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coenzimas / Ubiquitina-Proteína Ligases / Fatores de Transcrição de p300-CBP / Fator de Transcrição RelA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Coenzimas / Ubiquitina-Proteína Ligases / Fatores de Transcrição de p300-CBP / Fator de Transcrição RelA Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2009 Tipo de documento: Article