High and low birth weight and its implication for growth and bone development in childhood and adolescence.
J Pediatr Endocrinol Metab
; 22(1): 19-30, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19344071
ABSTRACT
AIM:
To investigate the relationship of birth weight (BW) to anthropometric measures, local body composition and bone development. POPULATION ANDMETHODS:
284 individuals (age 5-19 yr, 145 females) were recruited from the Dortmund Nutritional and Anthropometric Longitudinally Designed (DONALD) study. Parameters of bone development (cortical bone mineral density [BMDcort], endosteal circumference [CE]) and of local body composition (cross-sectional fat area [FA]) were analyzed by pQCT at the forearm. Parameters were transformed into SD scores to adjust for age or height.RESULTS:
BW predicted weight-SDS (R = 0.221), height-SDS (R = 0.260) and FA-SDS (R = 0.150). Individuals with lower BW (< 10th percentile) had lower weight-SDS (p < 0.01), height-SDS (p < 0.01), BMDcort-SDS (p = 0.02) and higher CE-SDS (p = 0.05). BMDcort was correlated with BW (r = -0.319) and FA (r = -0.283) in pubertal females.CONCLUSION:
BW is characterized by direct and indirect effects on growth, body composition and bone development.
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Base de dados:
MEDLINE
Assunto principal:
Desenvolvimento Ósseo
/
Macrossomia Fetal
/
Recém-Nascido de Baixo Peso
/
Desenvolvimento Infantil
/
Desenvolvimento do Adolescente
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Female
/
Humans
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Male
/
Newborn
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article