Chromosome instability is common in human cleavage-stage embryos.
Nat Med
; 15(5): 577-83, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19396175
ABSTRACT
Chromosome instability is a hallmark of tumorigenesis. This study establishes that chromosome instability is also common during early human embryogenesis. A new array-based method allowed screening of genome-wide copy number and loss of heterozygosity in single cells. This revealed not only mosaicism for whole-chromosome aneuploidies and uniparental disomies in most cleavage-stage embryos but also frequent segmental deletions, duplications and amplifications that were reciprocal in sister blastomeres, implying the occurrence of breakage-fusion-bridge cycles. This explains the low human fecundity and identifies post-zygotic chromosome instability as a leading cause of constitutional chromosomal disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fertilização in vitro
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Perda de Heterozigosidade
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Polimorfismo de Nucleotídeo Único
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Instabilidade Cromossômica
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Embrião de Mamíferos
Limite:
Adult
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Female
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Humans
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Pregnancy
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article