Circadian rhythm of neutrophil counts and granulocyte macrophage-colony stimulating factor (GM-CSF) under clozapine treatment: a case report.
World J Biol Psychiatry
; 11(2 Pt 2): 511-3, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-19396726
ABSTRACT
UNLABELLED Agranulocytosis is a severe side effect of clozapine which requires stopping this medication immediately in the case of progressive neutropenia. There are, however, cases of benign neutropenia under clozapine that do not progress. The ability to predict progression vs. non-progression in neutropenia cases under clozapine would be highly valuable for avoiding unnecessary treatment withdrawals. In this context, we closely monitored circadian neutrophil counts and granulocyte macrophage-colony stimulating factor (GM-CSF) levels in a patient who had low normal neutrophil counts at baseline and developed neutropenia under clozapine treatment. METHODS:
Venous blood samples were drawn in close intervals for 4 weeks. At several time points blood was sampled in the morning between 0830 and 930 h and a second time in the afternoon between 1400 and 1500 h.RESULTS:
The circadian rhythm of neutrophil counts and GM-CSF levels was unchanged. There was no progression to agranulocytosis, and clozapine could be continued.CONCLUSIONS:
In view of the available literature and the presented case it is suggested that further studying of circadian profiles of neutrophil counts, neutrophil regulatory factors, such as GM-CSF, and their intercorrelation may help to find a biomarker of benign vs. malign neutropenia under clozapine.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fator Estimulador de Colônias de Granulócitos e Macrófagos
/
Ritmo Circadiano
/
Clozapina
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Analgésicos não Narcóticos
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Contagem de Leucócitos
/
Neutrófilos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
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Humans
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Male
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article