Ebolavirus VP35 interacts with the cytoplasmic dynein light chain 8.
J Virol
; 83(13): 6952-6, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19403681
ABSTRACT
The viral protein VP35 of ebolavirus (EBOV) is implicated to have diverse roles in the viral life cycle. We employed a yeast two-hybrid screen to search for VP35 binding partners and identified the cytoplasmic dynein light chain (DLC8) as a protein that interacts with VP35. Mapping analysis unraveled a consensus motif, SQTQT, within VP35 through which VP35 binds to DLC8. The disruption of DLC8 binding does not affect the ability of VP35 to inhibit type I IFN production. Given that VP35 from various EBOV species interacts with DLC8, this interaction may have a role in regulating the EBOV life cycle.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas do Core Viral
/
Dineínas
/
Ebolavirus
/
Nucleoproteínas
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article