Synthesis and therapeutic evaluation of pyridyl based novel mTOR inhibitors.
Bioorg Med Chem Lett
; 19(11): 2949-52, 2009 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-19409777
ABSTRACT
A series of novel cyanopyridyl based molecules (1-14) were designed, synthesized and probed for inhibition of mammalian target of rapamycin (mTOR) activity. Compound 14 was found to be a potent inhibitor of mTOR activity as assessed by enzyme-linked immunoassays and Western blot analysis. Most importantly, systemic application (intraperitoneal; ip) of compound 14 significantly suppressed macroscopic and histological abnormalities associated with chemically-induced murine colitis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Piridinas
/
Inibidores de Proteínas Quinases
/
Nitrilas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article