3D-DART: a DNA structure modelling server.
Nucleic Acids Res
; 37(Web Server issue): W235-9, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19417072
ABSTRACT
There is a growing interest in structural studies of DNA by both experimental and computational approaches. Often, 3D-structural models of DNA are required, for instance, to serve as templates for homology modeling, as starting structures for macro-molecular docking or as scaffold for NMR structure calculations. The conformational adaptability of DNA when binding to a protein is often an important factor and at the same time a limitation in such studies. As a response to the demand for 3D-structural models reflecting the intrinsic plasticity of DNA we present the 3D-DART server (3DNA-Driven DNA Analysis and Rebuilding Tool). The server provides an easy interface to a powerful collection of tools for the generation of DNA-structural models in custom conformations. The computational engine beyond the server makes use of the 3DNA software suite together with a collection of home-written python scripts. The server is freely available at http//haddock.chem.uu.nl/dna without any login requirement.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Software
/
DNA
/
Modelos Moleculares
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article