Investigations on topically applied vitamin A loaded amphiphilic cyclodextrin nanocapsules.
J Nanosci Nanotechnol
; 9(1): 640-5, 2009 Jan.
Article
em En
| MEDLINE
| ID: mdl-19441361
ABSTRACT
A new cholesteryl-cyclodextrin derivative, obtained by grafting a single cholesterol on a cyclodextrin, was proved suitable for the manufacture of nanocapsules. The chemical structure of Chol-betaCD-Ac was assessed using high resolution 1H-NMR. These nanocapsules were loaded with a lipophilic drug, i.e., vitamin A propionate (PRVA) which is a highly unstable and poorly water soluble molecule with a real interest in therapeutic. The oily nature of vitamin A propionate leads to the formation of nanocapsules with a reproductible size distribution and a long term stability. The colloidal suspension can be used to form a gel which allow to achieve penetration in the skin of the PRVA encapsulated.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Vitamina A
/
Portadores de Fármacos
/
Ciclodextrinas
/
Nanoestruturas
Limite:
Humans
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article