Serum matrix metalloproteinase levels correlate with brain injury in human immunodeficiency virus infection.
J Neurovirol
; 15(3): 275-81, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19444696
ABSTRACT
Circulating levels of specific matrix metalloproteinases (MMPs; 1 and 7) were evaluated as correlates of brain injury in eight individuals in advanced human immunodeficiency virus (HIV) infection. Neurological status was quantified in vivo with automated segmentation algorithms and with diffusion tensor imaging. Both metalloproteinases correlated with microstructural brain alterations and the degree of atrophy. MMPs may influence neurological outcome through involvement in neuroimmune response, blood-brain barrier permeability, leukocyte migration, and MMP-mediated neurotoxicity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Complexo AIDS Demência
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Metaloproteinase 1 da Matriz
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Metaloproteinase 7 da Matriz
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article